Table 1 Clinical features after treatment with infliximab.
Eye | Diagnosis | Clinical features of systemic disease | Initial visual acuity (VA) | Inflammatory activity before starting treatment with infliximab (using SUN citeria[9] | Activity 3 months from start of infliximab | Activity at 6 months | Activity at 9 months*/ 12 months† | Dose of infliximab and additional events | Final VA | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AC (grade cells) | Vitreous haze (BIO) | CMO Y/N | Number of active joints (n) | ||||||||||
A | RE | Psoriatic JIA | Polyarthritis, | 0.8 | +1 | 0 | Y | Improved activity and CMO | Inactive | Inactive† | 3 mg/kg | 0.2 | |
HLA B27+ | Psoriasis | 0 joints | Improved CMO | No CMO† | 1×ST | –0.2 | |||||||
LE | ANA− | Nail dystrophy | –0.1 | No inflammatory activity | 12 | 1 joint | 0 joints† | ||||||
Osteoporosis | |||||||||||||
Delayed growth | |||||||||||||
B | RE | Psoriatic JIA | Polyarthritis | –0.2 | No inflammatory activity | Improved activity | Worse activity | NA | 6 mg/kg | 0 | |||
Psoriasis | 1×ST | ||||||||||||
HLA B27+ | Growth failure | 3 | 0 joints | 0 joints | 1x intravit | ||||||||
LE | ANA− | Nail dystrophy, uveitis | 2.3 | +1 | +3 | N | LVit'y | 2.3 | |||||
C | RE | Systemic JIA | Polyarthritis | 0.2 | +2 | 0 | N | Unchanged | Improved activity | Worse† | 6 mg/kg | 0.2 | |
LE | ANA− | 0.6 | +2 | 0 | N | 2 | activity | 4 joints† | 0.2 | ||||
0 joints | 0 joints | ||||||||||||
D | RE | Sarcoidosis | Sarcoid polyarthritis, renal, skin, growth failure | 0.2 | +1 | 0 | N | Unchanged activity | Improved activity | Improved activity* | 6 mg/kg | 0.3 | |
R Vit'y | |||||||||||||
LE | 0.6 | +1 | 0 | N | 2 | 0 joints | 1 joint | 0 joints* | R intravit | 0.2 | |||
E | RE | Psoriatic JIA | Previous posterior fossa medulloblastoma | 0.2 | +2 | 0 | N | Improved activity | Inactive eyes | Inactive eyes* | 3 mg/kg | 0.2 | |
LE | ANA− | 1.0 | +1 | 0 | N | 1 | 0 joints | 0 joints | 0 joints* | L cataract extraction | 0.1 | ||
F | RE | Multisystem granulomatous disease | Polyarthritis, epitheloid granulomas of skin, small intestine involvement | 0.1 | +1 | 0 | N | 3 mg/kg | 0.1 | ||||
ANA+ | Inactive. | Inactive | |||||||||||
LE | ACE+ | 0.1 | +2 | 0 | N | 2 | 1 joint | 0 joints | NA | 0.1 |
AC, anterior chamber; ANA, antinuclear antibodies; Anterior chamber cells (from SUN workshop[10]: Grade cells in field 0<1, 0.5+ = 1–5, 1+ = 6–15, 2+ = 16–25, 3+ = 26–50, 4+ = 50; BIO, bioscore; CMO, cystoid macular oedema; HLA, human leucocyte antigen; Intravit, intravitreal steroid; JIA, juvenile idiopathic arthritis; LE, left eye; NA, patient did not receive treatment to this time period; RE right eye; ST subtenons steroid; unchanged, active, inactive and improved are clinical assessments of uveitis activity taken from the SUN workshop[10]; VA, visual acuity; Vit'y, vitrectomy.
*Patient treated for 9 months.
†Patient treated for 12 months.
‡Pre‐existing visual loss not related to uveitis.