Skip to main content
. 2006 Dec 14;66(6):840–841. doi: 10.1136/ard.2006.065441

Table 1 Clinical features after treatment with infliximab.

Eye Diagnosis Clinical features of systemic disease Initial visual acuity (VA) Inflammatory activity before starting treatment with infliximab (using SUN citeria[9] Activity 3 months from start of infliximab Activity at 6 months Activity at 9 months*/ 12 months† Dose of infliximab and additional events Final VA
AC (grade cells) Vitreous haze (BIO) CMO Y/N Number of active joints (n)
A RE Psoriatic JIA Polyarthritis, 0.8 +1 0 Y Improved activity and CMO Inactive Inactive† 3 mg/kg 0.2
HLA B27+ Psoriasis 0 joints Improved CMO No CMO† 1×ST –0.2
LE ANA− Nail dystrophy –0.1 No inflammatory activity 12 1 joint 0 joints†
Osteoporosis
Delayed growth
B RE Psoriatic JIA Polyarthritis –0.2 No inflammatory activity Improved activity Worse activity NA 6 mg/kg 0
Psoriasis 1×ST
HLA B27+ Growth failure 3 0 joints 0 joints 1x intravit
LE ANA− Nail dystrophy, uveitis 2.3 +1 +3 N LVit'y 2.3
C RE Systemic JIA Polyarthritis 0.2 +2 0 N Unchanged Improved activity Worse† 6 mg/kg 0.2
LE ANA− 0.6 +2 0 N 2 activity 4 joints† 0.2
0 joints 0 joints
D RE Sarcoidosis Sarcoid polyarthritis, renal, skin, growth failure 0.2 +1 0 N Unchanged activity Improved activity Improved activity* 6 mg/kg 0.3
R Vit'y
LE 0.6 +1 0 N 2 0 joints 1 joint 0 joints* R intravit 0.2
E RE Psoriatic JIA Previous posterior fossa medulloblastoma 0.2 +2 0 N Improved activity Inactive eyes Inactive eyes* 3 mg/kg 0.2
LE ANA− 1.0 +1 0 N 1 0 joints 0 joints 0 joints* L cataract extraction 0.1
F RE Multisystem granulomatous disease Polyarthritis, epitheloid granulomas of skin, small intestine involvement 0.1 +1 0 N 3 mg/kg 0.1
ANA+ Inactive. Inactive
LE ACE+ 0.1 +2 0 N 2 1 joint 0 joints NA 0.1

AC, anterior chamber; ANA, antinuclear antibodies; Anterior chamber cells (from SUN workshop[10]: Grade cells in field 0<1, 0.5+  = 1–5, 1+  = 6–15, 2+  = 16–25, 3+  = 26–50, 4+  = 50; BIO, bioscore; CMO, cystoid macular oedema; HLA, human leucocyte antigen; Intravit, intravitreal steroid; JIA, juvenile idiopathic arthritis; LE, left eye; NA, patient did not receive treatment to this time period; RE right eye; ST subtenons steroid; unchanged, active, inactive and improved are clinical assessments of uveitis activity taken from the SUN workshop[10]; VA, visual acuity; Vit'y, vitrectomy.

*Patient treated for 9 months.

†Patient treated for 12 months.

‡Pre‐existing visual loss not related to uveitis.