Figure 1 (A) Photograph of the right lower arm of patient three who developed lupus erythematosus (LE) skin lesions on the arms, trunk and face (biopsy specimen compatible with LE) from 9 weeks onwards during treatment with leflunomide. (B) Patient eight with reactivation of LE skin lesions on face and arms, responding well to local steroid treatment. (C) Patient 13 with lower leg leucocytoclastic vasculitis at the start of the study. (D) Patient 13 at week eight; disappearance of vasculitic purpura (beyond 24 weeks).