Figure 3 Phosphorylation of MAP kinases in third passage SFB from patients with RA and OA after stimulation with TNFα, the agonistic anti‐TNF‐R1 mAb HTR‐9, or the agonistic anti‐TNF‐R2 mAb UTR‐1. Stimulation of RA‐ and OA‐SFB (n = 4 each for p38 and JNK; n = 5 each for ERK) with TNFα for 20 minutes significantly induced the phosphorylation of p38 (A), ERK (B) and JNK kinase (C) through TNF‐R1. Bars indicate means (SEM). *p<0.05 for the comparison of non‐stimulated and stimulated cells; †p<0.05 for the comparison of RA‐ and OA‐SFB.