Table 1 Clinical profiles of patients from whom polyclonal anti‐β2GPI antibody preparations were made.
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | |
|---|---|---|---|---|---|
| Sex/age | F/33 | F/53 | F/54 | F/38 | F/59 |
| Diagnosis | PAPS | PAPS | PAPS | PAPS | PAPS |
| Clinical features of APS | 1 DVT, 1 PE, PET, TIAs and stroke | 1 DVT, 3 PE | 1 DVT, 2 stillbirths, 1 PE, CVD, catastrophic APS | PVD, TIAs, brachial artery thrombosis | 3 Foetal losses, microinfarct CNS, MI, abnormal MRI, aortic stenosis |
| IgG aCL (GPL U/ml) | 350 | 223 | 142 | 257 | 308 |
| Lupus anticoagulant | + | + | + | + | + |
| Experimental procedures | Microarray, real time RT‐PCR, ELISA | Microarray, real time RT‐PCR, ELISA | Microarray, ELISA | Microarray, real time RT‐PCR, ELISA | Real time RT‐PCR |
aCL, anticardiolipin; CVD, cerebral vascular disease; DVT, deep vein thrombosis; MI, myocardial infarction; PE, pulmonary embolism; PET, pre‐eclampsia; PVD, peripheral vascular disease; TIA, transient ischemic attack.