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. 2007 Jan 12;66(8):1000–1007. doi: 10.1136/ard.2006.063909

Table 2 Anti‐β2GPI antibody‐induced gene expression in HUVEC.

Gene Induction (‐fold) Accession no. Gene description Gene Induction (‐fold) Accession no. Gene description
Apoptosis/anti‐apoptosis Metabolism
BCL2A1 14.4 NM_004049 BCL2‐related protein A1 SLC7A5 4.7 AB018009 Solute carrier family 7 (cationic amino acid transporter)
TNAIP8 3.8 NM_014350 Tumour necrosis factor α‐induced protein 8 PPAP2B 4.2 AB000889 Phosphatidic acid phosphatase type 2B
TNFAIP3 3.6 NM_006290 Tumour necrosis factor α‐induced protein 3 ASNS 3.5 NM_001673 Asparagine synthetase
TRAF1 3.5 NM_005658 TNF receptor‐associated factor INDO 3.3 M34455 Indoleamine‐pyrrole 2,3 dioxygenase
BIRC3 3.4 U37546 Baculoviral IAP repeat‐containing 3 GCH1 2.9 NM_000161 GTP cyclohydrolase 1 (dopa‐responsive dystonia)
CARD15 3.0 NM_022162 Caspase recruitment domain family, member 15 S100A3 2.8 NM_002960 S100 calcium binding protein A3
RIPK2 2.5 AF027706 Receptor‐interacting serine‐threonine kinase 2 SDC4 2.6 NM_002999 Syndecan 4 (amphiglycan, ryudocan)
TRIB3 2.3 NM_021158 Tribbles homolog 3 (Drosophila) MSCP 2.5 BE677761 Solute carrier family 25, member 37
GFPT2 2.5 NM_005110 Glutamine‐fructose‐6‐phosphate transaminase 2
Adhesion molecules/receptors MT1X 2.3 NM_002450 Metallothionein 1X
TNFAIP6 21.3 NM_007115 Tumour necrosis factor α‐induced protein 6 MTIE 2.3 BF217861 Metallothionein 1E (functional)
TNFRSF1 5.0 NM_002546 Tumour necrosis factor receptor superfamily, member 11b PDLM4 2.3 AF153882 PDZ and LIM domain 4
LLT1 4.7 NM_013269 C‐type lectin domain family 2, member D LIPG 2.3 NM_006033 Lipase, endothelial
BDKRB2 4.7 NM_000623 Bradykinin receptor B2 KCNMB1 2.2 U61536 Potassium large conductance calcium‐activated channel
TNC 4.5 NM_002160 Tenascin C (hexabrachion) OASL 2.2 NM_00373 2′‐5′‐Oligoadenylate synthetase‐like
TNFRSF9 4.4 NM_001561 Tumour necrosis factor receptor superfamily, member 9 Miscellaneous
OLR1 4.4 AF035776 Oxidised low density lipoprotein (lectin‐like) receptor 1 TNFAIP2 9.7 NM_006291 Tumour necrosis factor α‐induced protein 2
IL18R1 4.3 NM_003855 Interleukin 18 receptor 1 DD1T4 2.8 NM_019058 DNA‐damage‐inducible transcript 4
E‐Selectin 3.8 NM_000450 Selectin E (endothelial adhesion molecule 1) IFIT3 2.5 NM_001549 Interferon‐induced protein with tetratricopeptide repeats 3
ICAM 3.4 NM_000201 Intercellular adhesion molecule 1 (CD54) IFIT2 2.3 BE888744 Interferon‐induced protein with tetratricopeptide repeats 2
ICOSL 3.1 AL355690 Inducible T‐cell co‐stimulator ligand MOX2 2.2 H23979 CD200 antigen
CCRL2 3.0 AF015524 Chemokine (C‐C motif) receptor‐like 2 ZC3HV1 2.2 NM_020119 Zinc finger CCCH‐type, antiviral 1
PDZK3 2.8 AF338650 PDZ domain containing 3 CDC42 2.1 AI754416 CDC42 effector protein (Rho GTPase binding) 3
CD69 2.6 L07555 CD69 antigen (p60, early T‐cell activation antigen) MSCP 2.1 NM_018579 Solute carrier family 25, member 37
IFRG28 2.5 NM_022147 28kD Interferon responsive protein AIMI 2.1 U83115 Absent in melanoma 1
JAG1 2.3 U61276 Jagged 1 (Alagille syndrome) CHST5 2.1 N32257 Carbohydrate metabolism N‐acetylglucosamine metabolism
PTHLH 2.2 BC005961 Parathyroid hormone‐like hormone NAV3 2.0 NM_014903 Neuron navigator 3
EB13 2.2 NM_005755 Epstein‐Barr virus induced gene 3 ST5 2.0 NM_005418 Suppression of tumourigenicity 5
VCAM 2.2 NM_001078 Vascular cell adhesion molecule 1 FLJ23231 2.0 NM_025079 Zinc finger CCCH‐type containing 12A
CD83 2.1 NM_004233 CD83 antigen (immunoglobulin superfamily)
PDGFRA 2.1 NM_006206 Platelet‐derived growth factor receptor α polypeptide Transcription factors/signalling
HRH1 2.1 D28481 Histamine receptor H1 NKX31 6.3 AF247704 Transcription factor related, locus 1 (Drosophila)
IL1R1 2.1 NM_000877 Interleukin 1 receptor, type I SOD2 5.7 AL050388 Superoxide dismutase 2, mitochondrial
CEBPD 5.6 NM_005195 CCAAT/enhancer binding protein (C/EBP), delta
Coagulation HIVER2 4.4 AL023584 Human immunodeficiency virus type I enhancer binding protein 2
F3 3.3 NM_001993 Coagulation factor III (tissue factor) DSCR1 3.7 NM_004414 Down syndrome critical region gene 1
Transcription factors signalling continued RAPGEF5 3.4 NM_012294 Rap guanine nucleotide exchange factor (GEF) 5
Cytokines/chemokines STC2 3.2 BC000658 Stanniocalcin 2
CCL20 27.0 NM_004591 Macrophage inflammatory protein‐ MIP‐3 NCF4 2.9 NM_013416 Neutrophil cytosolic factor 4, 40 kDa
CXCL3 14.7 NM_002090 Chemokine (C‐X‐C motif) ligand 3 APOL3 2.7 NM_014349 Apolipoprotein L3
CSF2 11.6 M11734 Colony stimulating factor 2 (granulocyte‐macrophage) SNFT 2.6 NM_018664 Jun dimerisation protein p21SNFT
CX3CL1 10.5 NM_002996 Fractalkine RND1 2.6 U69563 Rho family GTPase 1
CSF3 6.9 NM_000759 Colony stimulating factor 3 (granulocyte) MAP3K8 2.6 NM_005204 Mitogen‐activated protein kinase kinase kinase 8
IL6 6.0 NM_000600 Interleukin 6 (interferon β2) FOXF1 2.5 NM_001451 Forkhead box F1
CXCL5 5.6 AK026546 Chemokine (C‐X‐C motif) ligand 5 IRF1 2.5 NM_002198 Interferon regulatory factor 1
IL1β 5.1 NM_000576 Interleukin 1β MSC 2.4 AF060154 Musculin (activated B‐cell factor‐1)
CXCL2 4.1 M57731 Chemokine (C‐X‐C motif) ligand 2
FGF18 4.1 NM_003862 Fibroblast growth factor 18 RGS2 2.3 NM_002923 Regulator of G‐protein signalling 2, 24 kDa
CXCL1 4.0 NM_001511 Chemokine (C‐X‐C motif) ligand 1 STAT5A 2.2 NM_003152 Signal transducer and activator of transcription 5A
LIF 3.6 NM_002309 Leukaemia inhibitory factor (cholinergic differentiation factor) MEOX1 2.2 NM_004527 Mesenchyme homeo box1
CXCL10 3.3 NM_001565 Chemokine (C‐X‐C motif) ligand 10 NFKB1 2.2 M55643 Nuclear factor of kappa light polypeptide gene enhancer
CXCL11 2.3 AF030514 Chemokine (C‐X‐C motif) ligand 11 ISG20 2.2 NM_002201 Interferon stimulated exonuclease gene 20 kDa
LTB 2.3 NM_002341 Lymphotoxin β (TNF superfamily, member 3) ABTB2 2.2 AL050374 Ankyrin repeat and BTB (POZ) domain containing 2
IL8 2.2 AF043337 Interleukin 8
CCL5 2.1 NM_002985 Chemokine (C‐C motif) ligand 5
CCL8 2.1 AI984980 Chemokine (C‐C motif) ligand 8
PBEF1 2.0 BF575514 Pre‐B‐cell colony enhancing factor 1
CSF1 2.0 M37435 Colony stimulating factor 1