Current-voltage relationships in oocytes expressing R-eag (A) or Shaker H4 (B) channels, before (open circles) and after the injection of MPF (closed circles). In B, both curves are overlapping. (C) Reduction of current amplitude induced by the injection of MPF, or heat-inactivated MPF, into Xenopus oocytes expressing R-eag, or MPF into oocytes expressing either Shaker H4 or Kv1.4 channels.