Table 2 Plasma median osteopontin levels in patients with gastric cancer with different clinicopathological features.
| Plasma OPN level (ng/ml) Median (mean±SE) | p Value* | |
|---|---|---|
| Helicobacter pylori | ||
| Seronegative (n = 51) | 78.6 (94.2±10.9) | |
| Seropositive (n = 81) | 78.0 (86.2±7.2) | NS |
| Stage | ||
| I (n = 42) | 59.3 (66.1±8.2) | |
| II (n = 23) | 63.7 (74.5±8.2) | NS† |
| III (n = 40) | 89.9 (96.9±10.6) | 0.003† |
| IV (n = 27) | 97.0 (126.9±18.8) | <0.001† |
| Serosal invasion | ||
| Absent (n = 52) | 66.3 (73.6±7.4) | |
| Present (n = 80) | 84.2 (99.5±8.7) | 0.017 |
| Lymph node metastasis | ||
| Absent (n = 49) | 63.3 (68.9±7.1) | |
| Present (n = 83) | 90.2 (101.6±8.5) | 0.003‡ |
| pN1 (n = 56) | 82.9 (94.7±9.4) | 0.018‡ |
| pN2, N3 (n = 27) | 92.4 (115.8±17.3) | 0.003‡ |
| Lymphatic invasion | ||
| Absent (n = 76) | 64.5 (76.0±6.9) | |
| Present (n = 56) | 91.8 (107.5±10.5) | 0.003 |
| Venous invasion | ||
| Absent (n = 77) | 63.7 (82.8±8.3) | |
| Present (n = 55) | 84.1 (98.5±8.9) | 0.035 |
| Liver metastasis | ||
| Absent (n = 124) | 75.6 (82.2±5.3) | |
| Present (n = 8) | 166.5 (200.2±45.3) | 0.002 |
*p Value calculated by non‐parametric Mann Whitney U test.
†Compared with stage I.
‡Compared with no lymph node metastasis.
NS, non‐significant; SE, standard error.