Table 2 Quality assessment of included studies.

	VISION5	MARINA8	ANCHOR9	FOCUS10
	Adequate	Adequate	Unclear	Unclear
	Adequate	Adequate	Unclear	Unclear
	Reported	Reported	Reported	Reported
	Adequate	Adequate	Adequate	Adequate
	Adequate	Adequate	Adequate	Inadequate*
	Adequate	Adequate	Adequate	Inadequate
	Adequate	Adequate	Adequate	Adequate
	Adequate	Adequate	Adequate	Adequate
	Inadequate	Adequate	Inadequate	Inadequate
	Partial	Adequate	Adequate	Adequate

Please see CRD reference for explanation of assessment criteria³.

*the VA assessor was masked to treatment assignment, but an unmasked investigator performed treatments and all other evaluations.