Table 1 Phlebotomy requirements and iron indices in 7 patients before and during PPI treatment (paired) and in 8 patients not prescribed a PPI (unpaired).

	Paired group (n = 7)			Unpaired group (n = 8)
	Before PPI	During PPI	p Value		p Value†	p Value‡
Recording period (years)	6.1 (0.2)*	3.8 (0.9)	0.2 NS	7.8 (1.5)	0.9 NS	0.06 NS
Haemoglobin (g/dl)	14 (0.2)	14.3 (0.4)	0.6 NS	13.5 (0.3)	0.7 NS	0.3 NS
Serum ferritin (µg/l)	81.4 (17.1)	38.5 (8.5)	0.1 NS	55.3 (4.7)	0.3 NS	0.9 NS
Annual phlebotomy requirements (litres)	2.5 (0.2)	0.5 (0.2)	<0.001	2.3 (0.1)	1.0 NS	<0.001

NS, not significant.

*All values are mean (SEM) †compared to before PPI ‡compared to during PPI.