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Figure 2 IL31 induces STAT1, STAT3, ERK‐1/2, and Akt phosphorylation in IEC. Upon stimulation of HCT116 cells with IL31 (100 ng/ml), (A) STAT1 and (B) STAT3 proteins are phosphorylated. (C) Phospho‐ERK‐1/2 (p‐ERK) activation after IL31 stimulation (100 ng/ml). (D) IL31 induces Akt phosphorylation. Similar results were obtained for SW480 cells (data not shown). One representative experiment (n = 3) is shown.
