Table 2 Expression of Mib1, Cdx2, hTERT and pro‐caspase 3 in the three glandular zones (superficial/foveolar, proliferative and coiled portions) in the different histological categories.
| Marker expression according to glandular compartment | IM | t Test p value IM vs Indef‐NiN | Indef‐NiN | t Test p value Indef‐NiN vs LG‐NiN | LG‐NiN | ANOVA p value IM vs Indef‐NiN vs LG‐NiN |
|---|---|---|---|---|---|---|
| Mib1 | ||||||
| Superficial/foveolar zone | 0 | NS | 0.17 (0.61) | <0.001 | 1.37 (1.2) | <0.001 |
| Proliferative zone | 1.61 (0.62) | <0.001 | 2.39 (0.49) | NS | 2.48 (0.5) | <0.001 |
| Glandular coils | 0.05 (0.23) | NS | 0.14 (0.52) | 0.002 | 1.17 (1.25) | <0.001 |
| Cdx2 | ||||||
| Superficial/foveolar zone | 0.27 (0.65) | NS | 0.26 (0.53) | <0.001 | 1.58 (1.18) | <0.001 |
| Proliferative zone | 1.7 (0.66) | <0.001 | 2.42 (0.5) | 0.048 | 2.65 (0.48) | <0.001 |
| Glandular coils | 0.12 (0.47) | 0.035 | 0.5 (0.86) | <0.001 | 1.68 (1.36) | <0.001 |
| hTERT | ||||||
| Superficial/foveolar zone | 0 | NS | 0.07 (0.26) | <0.001 | 0.68 (0.74) | <0.001 |
| Proliferative zone | 0.81 (0.62) | <0.001 | 1.59 (0.69) | NS | 1.8 (0.57) | <0.001 |
| Glandular coils | 0.03 (0.47) | 0.02 | 0.33 (0.62) | NS | 0.52 (0.71) | <0.001 |
| Pro‐caspase 3 | ||||||
| Superficial/foveolar zone | 0.07 (0.33) | <0.001 | 0.5 (0.57) | 0.006 | 1.03 (0.89) | <0.001 |
| Proliferative zone | 1.28 (0.60) | <0.001 | 1.85 (0.52) | NS | 1.88 (0.97) | <0.001 |
| Glandular coils | 0.35 (0.52) | 0.039 | 0.64 (0.62) | NS | 0.74 (0.94) | <0.001 |
ANOVA, analysis of variance; Indef‐NiN, indefinite non‐invasive neoplasia; IM, intestinal metaplasia; LG‐NiN, low‐grade non‐invasive neoplasia; NS, not significant.