Table 4 Correlation between nuclear insulin receptor substrate 1, oestrogen receptor α and selected clinicopathological tumour features.
| Ductal carcinoma | Lobular carcinoma | ||||
|---|---|---|---|---|---|
| ERα | IRS‐1 | ERα | IRS‐1 | ||
| G | r | −0.573 | −0.511 | −0.563 | 0.029 |
| p Value | 0.001 | 0.0067 | 0.065 | 0.94 | |
| pT | r | −0.393 | −0.382 | −0.326 | 0.153 |
| p Value | 0.039 | 0.044 | 0.310 | 0.633 | |
| pN | r | −0.381 | −0.454 | −0.082 | −0.122 |
| p Value | 0.044 | 0.015 | 0.797 | 0.714 | |
| Ki67 | r | −0.591 | −0.538 | −0.329 | −0.016 |
| p Value | 0.001 | 0.003 | 0.31 | 0.94 | |
ERα, oestrogen receptor α; G, tumour grade; IRS‐1 insulin receptor substrate 1; pN, lymph node involvement; pT, tumour size; r, correlation coefficient.
The association between nuclear IRS‐1 or ERa and G, pT, pN, and the expression of the proliferation marker Ki67 was statistically analysed with Pearson's correlation test.