Table 3 Relationship between intrarenal gene expression and serological markers of lupus activity.
C3 | C4 | anti‐ds‐DNA antibody | ||||
---|---|---|---|---|---|---|
Glomerular | Tubulointerstitial | Glomerular | Tubulointerstitial | Glomerular | Tubulointerstitial | |
T‐bet | r = −0.725 | r = −0.451 | r = −0.809 | r = −0.513 | r = 0.976 | r = 0.613 |
p<0.001 | p = 0.006 | p<0.001 | p = 0.001 | p<0.001 | p<0.001 | |
GATA‐3 | r = −0.225 | r = −0.003 | r = −0.202 | r = −0.123 | r = 0.607 | r = 0.327 |
p = 0.2 | p = 0.9 | p = 0.2 | p = 0.5 | p<0.001 | p = 0.052 | |
IFNγ | r = −0.545 | r = −0.396 | r = −0.394 | r = −0.057 | r = 0.369 | r = −0.008 |
p<0.001 | p = 0.014 | p = 0.014 | p = 0.7 | p = 0.023 | p = 0.9 | |
IL2 | r = −0.352 | r = −0.335 | r = −0.419 | r = −0.220 | r = 0.234 | r = 0.371 |
p = 0.03 | p = 0.04 | p = 0.011 | p = 0.2 | p = 0.16 | p = 0.022 | |
IL4 | r = −0.199 | r = −0.217 | r = −0.099 | r = −0.199 | r = 0.154 | r = 0.234 |
p = 0.231 | p = 0.2 | p = 0.6 | p = 0.2 | p = 0.4 | p = 0.16 | |
IL10 | r = −0.302 | r = −0.165 | r = −0.323 | r = −0.056 | r = 0.254 | r = 0.234 |
p = 0.065 | p = 0.3 | p = 0.048 | p = 0.7 | p = 0.12 | p = 0.16 | |
IL12 | r = −0.156 | r = 0.101 | r = −0.323 | r = 0.143 | r = 0.254 | r = −0.152 |
p = 0.3 | p = 0.5 | p = 0.048 | p = 0.4 | p = 0.12 | p = 0.4 | |
IL18 | r = −0.200 | r = 0.113 | r = −0.237 | r = 0.309 | r = 0.178 | r = −0.277 |
p = 0.2 | p = 0.5 | p = 0.2 | p = 0.059 | p = 0.3 | p = 0.09 | |
TGFβ | r = −0.172 | r = 0.063 | r = −0.232 | r = 0.163 | r = 0.161 | r = −0.133 |
p = 0.3 | p = 0.7 | p = 0.2 | p = 0.3 | p = 0.3 | p = 0.4 | |
MCP‐1 | r = −0.405 | r = −0.068 | r = −0.374 | r = 0.127 | r = 0.311 | r = −0.043 |
p = 0.014 | p = 0.7 | p = 0.021 | p = 0.4 | p = 0.057 | p = 0.8 |
ds, double strand; IFN, interferon; IL, interleukin; TGF, transforming growth factor.