Table 3 Hazard ratios for all‐cause mortality according to quartiles of carbohydrate antigen 125 serum levels.
| Cox regression models | HR (95% CI) | p Value | Harrell's C statistics |
|---|---|---|---|
| Unadjusted HRs | |||
| CA125, U/ml*† | 2.73 (1.81 to 4.10) | <0.001 | 0.656 |
| CA125 quartiles (min and max values, U/ml) | 0.659 | ||
| Q1 (4.6–25.1) | 1 | ||
| Q2 (25.3–60.3) | 4.17 (1.57 to 11.12) | 0.004 | |
| Q3 (61.2–141.5) | 6.61 (2.56 to 17.07) | <0.001 | |
| Q4 (141.7–1169.5) | 8.27 (3.24 to 21.11) | <0.001 | |
| CA125 >35 U/ml | 2.79 (1.60 to 4.86) | <0.001 | 0.596 |
| CA125 >60 U/ml | 2.91 (1.83 to 4.62) | <0.001 | 0.630 |
| Adjusted HRs‡ | |||
| CA125, U/ml* | 2.83 (1.81 to 4.42) | <0.001 | 0.816 |
| CA125 quartiles (min and max values, U/ml) | 0.815 | ||
| Q1 (4.6–25.1) | 1 | ||
| Q2 (25.3–60.3) | 3.25 (1.20 to 8.79) | 0.020 | |
| Q3 (61.2–141.5) | 4.91 (1.88 to 12.85) | 0.001 | |
| Q4 (141.7–1169.5) | 8.41 (3.24 to 21.79) | <0.001 | |
| CA125 >35 U/ml | 2.41 (1.37 to 4.24) | 0.002 | 0.803 |
| CA125 >60 U/ml | 2.86 (1.77 to 4.62) | <0.001 | 0.810 |
CA125, carbohydrate antigen 125; HRs, hazard ratios; max, maximum; min, minimum; Q, quartile.
*Per 25–75th centile change.
†Area under the curve (95% CI) calculated by receiver operating characteristic curve analysis = 0.667 (0.61 to 0.72)
‡Cox model adjusted by age, gender, diabetes and their interaction (gender×diabetes), New York Heart Association class III/IV, aetiology of valvular heart disease, systolic blood pressure, serum creatinine and haemoglobin.