Table 1.
Demographic and clinical characteristics of 502 children with acute pyelonephritis (APN) according to allocation to new treatment (oral co-amoxiclav) or standard treatment (intravenous ceftriaxone followed by oral co-amoxiclav)
| New treatment (n=244) | Standard treatment (n=258) | |
|---|---|---|
| Age (months): | ||
| Median (range) | 8.1 (1-81) | 7.9 (1-99) |
| Mean (SD) | 12.7 (14.2) | 11.9 (13.9) |
| No of children | 244 | 258 |
| No (%) girls | 159/244 (65.2) | 163/258 (63.2) |
| Max body temperature (°C): | ||
| Median (range) | 39.25 (36.5-41) | 39.2 (36.8-41.5) |
| Mean (SD) | 39.1 (0.77) | 39.2 (0.78) |
| No of children | 240 | 255 |
| White cell count (×109/l): | ||
| Median (range) | 17.2 (5.5-45.9) | 17.0 (3.8-37.1) |
| Mean (SD) | 18.1 (6.4) | 17.8 (6.0) |
| No of children | 243 | 257 |
| Neutrophils (×109/l): | ||
| Median (range) | 9.6 (1.5-29.1) | 9.9 (1.6-29.1) |
| Mean (SD) | 10.8 (5.0) | 10.7 (5.0) |
| No of children | 218 | 210 |
| Erythrocyte sedimentation rate (mm in first hour): | ||
| Median (range) | 58 (1-150) | 65 (1-122) |
| Mean (SD) | 59.7 (28.9) | 66 (28.5) |
| No of children | 153 | 150 |
| C reactive protein (mg/l)*: | ||
| Median (range) | 12.5 (0.1-168) | 14.2 (0.1-172) |
| Mean (SD) | 17.9 (19.6) | 19.6 (20.6) |
| No of children | 243 | 257 |
| No (%) with confirmed APN† | 135/216 (62.5) | 143/222 (64.4) |
| No (%) with VUR | 53/231 (22.9) | 49/242 (20.2) |
| VUR grade: | ||
| 1 | 11 | 13 |
| 2 | 18 | 19 |
| 3 | 21 | 13 |
| 4 | 3 | 3 |
| 5 | 0 | 1 |
VUR=vesicoureteric reflux.
*Ratio between obtained value and upper limit of normal reference values for each laboratory.
†Confirmed with scintigraphy in children who underwent scan within 10 days after start of antibiotic treatment.