Table 3.
Comparison of structural features in homologues of citrate synthase.
| PaCS | PfCS | SsCSa | PigCS | ArCSb | |
|---|---|---|---|---|---|
| Optimal Temp (C°) | 100 | 100 | 85 | 37 | 31 |
| Sequence Identity (%)c | - | 46 | 44 | 27 | 35 |
| Sequence Length | 409 | 377 | 377 | 464 | 379 |
| ASA (×104 Å2) | 3.02 | 2.66 | 2.77 | 3.27 | 2.66 |
| ASA/residue (Å2) | 73.8 | 70.6 | 73.5 | 70.5 | 70.2 |
| Interface ASA (%) | 25.9 | 22.6 | 19.8 | 24.0 | 21.0 |
| Volume (×104 Å3) | 8.65 | 7.89 | 7.74 | 8.93 | 7.63 |
| Volume/residue (Å3) | 211.5 | 209.3 | 205.3 | 192.5 | 201.3 |
| Hydrophobic (%)d | 40.3 | 39.0 | 40.3 | 38.7 | 40.4 |
| Charged (%)e | 24.2 | 26.5 | 26 | 20.4 | 23.2 |
| Total Ion Pairs | 65 | 43 | 45 | 36 | 52 |
| Interface H-Bonds | 47 | 54 | 28 | 42 | 44 |
| Length of Loops | 101 | 106 | 109 | 116 | 114 |
a
From Sulfolobus solfataricus.
b
From Antarctic bacterium DS2-3R.
c
Calculated as identity to PaCS.
d
Hydrophobic residues Ala, Ile, Leu, Met, Phe, Trp, Val
e
Charged residues Arg, Lys, Asp, Glu