Figure 2 Caerulein‐induced pancreatic necrosis is less severe in PAP/HIP^−/− mice than in wild‐type mice. Plasmatic amylase (A) and lipase (B) levels were measured in control PAP/HIP^+/+, PAP/HIP^−/− and PAP/HIP^−/− treated with recombinant PAP/HIP mice at 9 and 21 hours after the first caerulein injection. (C) Representative images from control pancreas and pancreas after 9 hours of pancreatitis are shown. (D) Necrosis score of histological sections from control pancreas and pancreas after 9 and 21 hours after the induction of acute pancreatitis in PAP/HIP^+/+, PAP/HIP^−/− and PAP/HIP^−/− treated with recombinant PAP/HIP mice. Results are expressed as mean ± SE (n  =  8). ^#p<0.05 PAP/HIP^−/− vs PAP/HIP^+/+ mice. *p<0.05 vs respective control.