Table 1.
Schematic representation of group, stimulus conditions, and drug treatments for Experiments 1 & 2.
| Treatment Phase | ||||||||
|---|---|---|---|---|---|---|---|---|
| NIC Treatment I | NIC Treatment II | Withdrawal | ||||||
| Group | Stimulus | PRE | POST | PRE | POST | PRE | POST | |
| Experiment 1 | HL-OFF-NIC (n=8) | 5-s house-light off + 5-s tone | SAL | ----- | ||||
| HL-OFF-SAL (n=7) | NIC | ----- | ||||||
|
|
||||||||
| STIM-ON-NIC (n=8) | 5-s stimulus-light on + 5-s tone (red house light) | SAL | ----- | |||||
| STIM-ON-SAL (n=8) | NIC | ----- | ||||||
|
| ||||||||
| Experiment 2 | NIC/SAL (n=8) | 5-s house-light off + 5-s tone | NIC | SAL | NIC | SAL | SAL | SAL |
| SAL/NIC Control (n=8) | SAL | NIC | SAL | NIC | SAL | SAL | ||
| SAL/NIC Switched (n=7) | SAL | NIC | NIC | SAL | SAL | SAL | ||
| SAL/SAL (n=8) | SAL | SAL | SAL | SAL | SAL | SAL | ||
PRE: injection occurs 5-min before test session; POST: injection occurs 1-h after test session; NIC: 0.4 mg/kg (free base) nicotine injection; SAL: 0.9% saline injection. Shaded cells represent control group treatments (pre-test injection was always saline). Houselights were white during test sessions unless otherwise specified.