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. Author manuscript; available in PMC: 2007 Sep 21.
Published in final edited form as: Diabetes. 2007 Mar;56(3):786–794. doi: 10.2337/db06-0187

Figure 2. Electron microscopic images of left ventricle and papillary muscles from control (A, B) and AMPKα2−/− (C–F) mice.

Figure 2

(A) Overview of a control myocyte in longitudinal section, with mitochondria and myofibrils arranged in regular longitudinal columns. (C and E) Longitudinal section of cardiomyocytes from papillary (C) and ventricular (E) muscles from AMPKα2−/− mice showing myofibrillar disorganization, and irregular arrangement of intermyofibrillar mitochondria with clusters of mitochondria of variable size. (B) Detail of sarcomeres in a control myocyte, showing mitochondria tightly packed along sarcomeres. (D and F) Details of sarcomeres in AMPKα2−/− myocytes from papillary (D) and ventricular (F) muscles, showing dense packing of mitochondria of irregular size. Asterisk: large mitochondria having irregular shape. Arrows: splitting of myofibrils. Arrowhead: dividing mitochondrion.