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. Author manuscript; available in PMC: 2007 Sep 21.
Published in final edited form as: Diabetes. 2007 Mar;56(3):786–794. doi: 10.2337/db06-0187

Figure 3. A. Decreased substrate utilization by cardiac mitochondria in AMPKa2−/− mice.

Figure 3

Respiration rates were measured during the cumulative addition of substrates in saponin-skinned cardiac fibers of control and AMPKα2−/− mice. VO2: rate of O2 consumption in μmol.min−1.g dw−1. G3P: glycerol-3-phosphate, Mai: malate, Oct: octanoyl-carnitine, Pyr: pyruvate, Glu: glutamate. * p<0.05 versus control. B. Respiration rate through complex-I is specifically inhibited in AMPKa2−/− mouse heart. VO2: Rate of O2 consumption in μmol.min−1.g dw−1 in saponin-permeabilized cardiac fibers. Complex-I: respiration with 2mmol/l malate and 5mmol/l glutamate. Complex-II: respiration with 10mmol/l succinate. * p<0.05 versus control.