Table 2.
Functional data
| Wild type (n=5) | AMPKα2−/− (n=5) | |||
|---|---|---|---|---|
| glucose | glucose+oleate | glucose | glucose+oleate | |
| Ventricular pressure, mmHg | 87±7 | 109±7 | 85±5 | 118±6 |
| Heart rate, beats/min | 358±18 | 317±17 | 365±9 | 337±16 |
| Rate Pressure product, RPP | 2.9±0.1 | 3.2±0.1 | 2.9±0.2 | 3.6±0.2 |
| +DP/dt, mmHg.sec−1 | 3818±229 | 4088±264 | 3778±356 | 4533±465 |
| −DP/dt, mmHg.sec−1 | −2719±187 | −3053±131 | −2513±153 | −3167±141 |
| Oxygen consumption rate, QO2 | 6.4±0.7 | 8.6±0.7* | 6.0±0.6 | 8.0±1.0 |
| QO2/RPP | 2.3±0.3 | 2.7±0.3 | 2.1±0.3 | 2.3±0.3 |
Hearts were first perfused with glucose 11 mM and then with glucose 5 mM and 0.4 mM oleate. Values are means ± S.E.M., n = number of mice; RPP: 104.mmHg.beats.min−1. QO2: μmol O2.min−1.g−1 ww. No statistical difference between control and AMPKα2−/−.
*
p <0.05, glucose versus glucose + oleate.