Table 4.
Fatty acid composition of cardiac lipids
| Fatty acid | COMPOSITION (%)
|
|||||
|---|---|---|---|---|---|---|
| Heart Mitochondria
|
Heart Phospholipids
|
Non phosphorous Lipids
|
||||
| Control | AMPKα2−/− | Control | AMPKα2−/− | Control | AMPKα2−/− | |
| 16:0 | 13.4±0.6 | 14.6±0.7 | 14.2±0.9 | 16.4±0.5 | 19.8±0.5 | 18.1±0.4 |
| 16:1 w9 | 1.1±0.2 | 1.0±0.3 | 0.3±0.1 | 0.35±0.03 | 6.2±0.7 | 4.5±0.3 |
| 18:0 | 18±1 | 17±1 | 21±1 | 21±1 | 8.9±0.3 | 9±1 |
| 18:1 w9 | 6.7±0.3 | 7.0±0.2 | 6.3±0.3 | 6.3±0.3 | 19.0±0.4 | 22.0±0.4* |
| 18:1 w7 | 2.51±0.03 | 2.7±0.1 | 2.26±0.04 | 2.5±0.1 | 1.4±0.1 | 1.5±0.3 |
| 18:2 w6 LA | 19.2±0.6 | 16.8±0.4* | 18.0±0.2 | 16.3±0.5* | 20.1±1.5 | 24.3±0.3* |
| 20:4 w6 | 4.5±0.2 | 4.3±0.2 | 5.2±0.2 | 4.9±0.3 | 3.0±0.1 | 2.6±0.4 |
| 22:5 w3 | 1.02±0.03 | 1.2±0.1 | 1.1±0.1 | 4.1±3.1 | 1.5±0.1 | 1.5±0.4 |
| 22:6 w3 | 30±2 | 31±2 | 28±2 | 24±1 | 5.1±0.4 | 5.4±0.6 |
| SFA | 32±1 | 33±1 | 36±2 | 34±5 | 36±1 | 39±5 |
| MUFA | 12±1 | 11±1 | 9.7±0.3 | 9±1 | 31±1 | 36±6 |
| PUFA w6 | 25.1±0.5 | 22.5±0.6* | 25.2±0.4 | 20±3 | 25±1 | 33±5 |
| PUFA w3 | 31±2 | 33±2 | 29±2 | 24±4 | 8.1±0.3 | 9±1 |
Values are means ± S.E.M.
*
p<0.05. SFA: saturated fatty acids. MUFA, mono-unsaturated fatty acids. PUFA: polyunsaturated fatty acids. LA, linoleic acid. Three control and three AMPKα2−/− mice were used.