Table 3.
B cell subsets in spleen of Itpkb−/− Eμ-2–22 BCL-2 and Itpkb−/−Bim+/− mice, based on IgM/IgD staining (mean ± SD, ×106)
| Mice | n | T1-MZ (IgM++ IgD−) | T2 (IgM++ IgD+) | FoM (IgM+ IgD+) |
|---|---|---|---|---|
| Itpkb+/+ | 5 | 7.97 ± 4.02 | 7.67 ± 4.06 | 17.4 ± 7.78 |
| Itpkb−/− | 3 | 4.89 ± 2.53 | 2.05 ± 1.37 | 7.08 ± 3.15 |
| Itpkb+/+Bim+/− | 4 | 10.6 ± 3.5 | 14.9 ± 4.3 | 40.5 ± 7.2 |
| Itpkb−/−Bim+/− | 7 | 12.0 ± 3.6* | 6.5 ± 1.9* | 26.9 ± 7.1† |
| Itpkb−/− Eμ-2–22 BCL-2 | 2 | 6.1 ± 2.1 | 5.7 ± 0.8 | 40.4 ± 7.0 |
Statistical analysis is based on one-way ANOVA and Bonferroni's multiple comparison test for Itpkb+/+ vs Itpkb−/−Bim+/− and Itpkb−/− vs. Itpkb−/−Bim+/− if significant one-way ANOVA for α=0.05. Itpkb+/+ and Itpkb−/−Bim+/− B cell populations are statistically the same; Itpkb−/− and Itpkb−/−Bim+/− B cell population are statistically different.
*, P < 0.05;
†, P < 0.01.