Fig. 1.
Phenotype of Foxc1hith/hith mice. (a) Whole mount and cross sections of Foxc1hith/hith eyes highlight the micropthalmalia, dysgenic iris (white arrow), and thickened cornea. The anterior chamber is also lost (the space between the lens and the cornea, black arrow) in the mutants. (Scale bars: 500 μm.) (b) Bony defects are limited to the frontal bone and sagittal suture in the Foxc1hith/hith. (c) Hemisections of cortex at three ages in control and mutant animals shows that major cortical dysplasia develops between E18.5 and P7. The dashed red line in the P7 mutant cortex shows the area of most severe dysplasia in dorsomedial cortical areas. The red arrows show the abnormally formed hippocampal layers, and the asterisk is placed in the dilated lateral ventricle in the adult mutant cortex. Note that there is not prominent ventricular dilatation at earlier ages. (d) Higher-magnification images showing three examples from different brains of heterotopic cells in the marginal zone of mutant neocortex (red arrows).