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Frequency of T cell hybridomas reactive to self MHC with or without exogenous antigen
| Source of T hybridomas | Responds to C57BL/10, % (n)
|
|
|---|---|---|
| Without OVA 323-339 | With OVA 323-339* | |
| ζKO | 20 (1/5) | 0 (0/5) |
| FcRγTG ζKO | 7 (10/144) | 75 (108/144) |
| ζ+ | 4 (4/96) | 80 (77/96) |
OVA, ovalbumin.
Similar percentages of autoreactive and antigen-reactive hybridomas were obtained from mice primed with Eα 52-68 peptide.
