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Linked epitopes on APCs are required for productive T cellular collaboration. Th cells were pulsed with HIV-gag, and CTLs were pulsed with KLH or not treated. The T cells were mixed at 1:1 ratios in starting numbers as indicated and coincubated with monocytes, expressing HIV-gag and KLH linked on one population (A) or separately pulsed with individual antigens and mixed (B). Cytolytic activity was determined by addition of 5000 51Cr-labeled and HIV-gag pulsed T2 cells as described.
