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. 1997 Jan 21;94(2):679–683. doi: 10.1073/pnas.94.2.679

Figure 4.

Figure 4

Inhibition of NOS activity reduces infarct size in skeletal muscle, but not in the heart. (a) When compared with vehicle-treated controls (open column, n = 9), the NOS inhibitors NG-methyl-l-arginine (3 mg·kg−1 i.a., black column, n = 3), 7-NI (30 mg·kg−1 i.p., gray column, n = 5), and AE-ITU (10 mg·kg−1 i.a., hatched column, n = 3) did not reduce infarct size in the heart. (b) When compared with vehicle-treated controls (open column; n = 18), the NOS inhibitors 7-NI (30 mg·kg−1 i.p., gray column, n = 10) and AE-ITU (10 mg·kg−1 i.v., hatched column, n = 12) caused a significant reduction in the degree of skeletal muscle infarction. ∗, P < 0.05 compared with control (ANOVA followed by Bonferoni’s test).