Table 2.
Combined analysis of CTL gene expression
| Gene | Rejection | Nonrejection | P* | Sensitivity, % | Specificity, % |
|---|---|---|---|---|---|
| P + GB one or both up-regulated | 11/12 | 5/28 | 0.00015* | 91 | 82 |
| FasL + GB one or both up-regulated | 12/12 | 4/28 | <0.0001* | 100 | 85 |
| FasL + GB + P any two up-regulated | 12/12 | 0/28 | <0.0001* | 100 | 100 |
Expression of an individual gene was deemed positive for values above the mean ± 95% confidence interval of nonrejecting kidneys (maximum 0.07 pg/pg of GAPDH for GB and 0.4 pg/pg of GAPDH for FasL and 0.8 pg/pg of GAPDH for P).
*
Statistical analysis was performed with a χ2 test.