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. 1997 Jan 21;94(2):719–723. doi: 10.1073/pnas.94.2.719

Figure 1.

Figure 1

Functional synaptic model. (A) Stimulation paradigm used to obtain the parameters for the model. (B) Postsynaptic potential generated by a regular spike train (Bottom), at a frequency of 23 Hz measured experimentally (Top; average more than 50 sweeps), and computed with the model (Middle). (C) Same as B for irregular spike train (different synaptic connection). Postsynaptic potential is computed using a passive membrane mechanism [τmem(dV/dt) = −V + RinIsyn(t)] with an input resistance of 100MΩ. τrec is obtained by measuring the time of recovery for a synapse after stimulating it with high frequency burst (single exponential). Other parameters are determined by iteratively comparing model and experimental traces until the best match with the initial (R1), transition (R2 and others), and stationary responses is achieved. Parameters in B: τinact = 3 msec, τrec = 800 msec, USE = 0.67, ASE = 250 pA, τmem = 50 msec. Parameters in C: τinact = 3 msec, τrec = 450 msec, USE = 0.55, ASE = 530 pA, τmem = 30 msec.