Figure 5.

Effect of P-selectin gene expression on mouse survival after frank pulmonary ischemia and reperfusion. Ischemic durations are shown. Animal survival was recorded at the 30-min time point after ligation of the right (nonischemic) pulmonary artery [n = 5 each for P-selectin null mice (P-selectin −/−) and wild-type controls (P-selectin +/+) at 30 min ischemia, and n = 10 each for P-selectin −/− and P-selectin +/+ mice at 60 min ischemia). Data are presented as the mean ± SEM.