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. 2007 Sep 5;2(9):e836. doi: 10.1371/journal.pone.0000836

Figure 4. RARα antagonists counteract both RA-induced growth inhibition and nSMase-mediated CER synthesis.

Figure 4

A) RO415253 (RO) (left) and ER50891 (ER) (right) rescued T47D cells from RA-induced growth-inhibition. B) Both RO and ER counteracted the RA-induced CER synthesis. C) Both RO and ER significantly counteracted the transcription of nSMase as well as the transcription of the control downstream RARα direct target RARβ2.