Figure 1. The Interactions among c-myc, the E2F1, E2F2, and E2F3 Transcription Factors and the microRNAs of the miR-17–92 Complex Are Shown.

Black arrows indicate a transcriptional induction. Bidirectional arrows indicate mutual transcriptional induction. Darker arrows indicate stronger evidence of regulation while dashed arrows indicate that the evidence is less conclusive. Red lines indicate translational inhibition. Darker lines indicate stronger inhibition and dashed lines indicate weaker inhibition. Among members of the miR-17–92 cluster, only miR-17–5p and miR-20a have been shown to inhibit E2F translation.