Table 1.
Characteristics of Ldlr−/−Apob100/100 mice with and without hCRP expression
| Variable | 15 weeks |
30 weeks |
40 weeks |
50 weeks |
||||
|---|---|---|---|---|---|---|---|---|
| CRP+/0 (n = 7) | CRP0/0 (n = 6) | CRP+/0 (n = 24) | CRP0/0 (n = 19) | CRP+/0 (n = 12) | CRP0/0 (n = 10) | CRP+/0 (n = 12) | CRP0/0 (n = 15) | |
| Weight | 26.3 ± 2.4 | 23.0 ± 1.5 | 33.0 ± 4.5 | 32.3 ± 3.7 | 35.0 ± 7.7 | 34.8 ± 6.3 | 35.2 ± 5.5 | 34.9 ± 5.6 |
| Cholesterol | 343 ± 3 | 330 ± 37 | 330 ± 55 | 308 ± 57 | 375 ± 150 | 356 ± 127 | 330 ± 41 | 377 ± 92 |
| Triglycerides | 134 ± 12 | 124 ± 11 | 147 ± 31 | 137 ± 25 | 199 ± 57 | 168 ± 66 | 137 ± 39 | 155 ± 61 |
| Glucose | 230 ± 104 | 142 ± 20 | 374 ± 96 | 399 ± 76 | 544 ± 177 | 541 ± 157 | 366 ± 109 | 375 ± 107 |
| SAA | 3.6 (2.8–11.3) | 6.0 (3.8–6.7) | 4.8 (1.5–19.9) | 1.9 (1.7–3.6) | 10.5 (1.2–27.5) | 34.3 (0.8–95.4) | 2.2 (0.4–54.9) | 8.3 (3–60.3) |
| CRP | 24.0 (22.5–33.5) | 0 (0) | 51.8 (45.1–59.2) | 0 (0) | 37.0 (28.6–59.3) | 0 (0) | 41.7 (38.7–53.3) | 0 (0) |
Values are mean ± SD and median (25th to 75th percentiles) in parentheses for SAA and CRP. There were no significant differences between the groups (CRP+/0 vs. CRP0/0) or within the groups between time points except for CRP, P < 0.003.