Motor impairment in Dbh−/− mice. Shown is the performance of Dbh−/− mice compared with control Dbh+/− mice on challenging beam traversal (a), frequency of abnormal involuntary movements (b), time to orient down in the pole test (c), and time to descend in the pole test (d). Control, n = 36; Dbh−/−, n = 37. **, P < 0.001 compared with control; ***, P < 0.0001 compared with control.