Table 1.
Echocardiographic Findings in Vehicle and M-CSF-Treated Mice after MI Induction
| Baseline | Day 7 | Day 14 | Day 21 | Day 28 | |
|---|---|---|---|---|---|
| Vehicle | |||||
| n | 24 | 24 | 23 | 6 | 6 |
| B.W. (g) | 25.1 ± 0.3 | 24.8 ± 0.5 | 26.0 ± 0.4 | 28.3 ± 0.2** | 28.5 ± 0.3** |
| B.W. (%) | 100 | 98.8 ± 0.9 | 102.5 ± 0.9 | 107.6 ± 2.0** | 108.3 ± 2.0** |
| IVSd (mm) | 0.74 ± 0.02 | 0.67 ± 0.03 | 0.65 ± 0.03 | 0.60 ± 0.02 | 0.55 ± 0.05* |
| LVDd (mm) | 4.04 ± 0.11 | 4.45 ± 0.10 | 4.92 ± 0.12** | 5.13 ± 0.17** | 5.22 ± 0.21** |
| LVPWd (mm) | 0.82 ± 0.03 | 0.90 ± 0.05 | 0.85 ± 0.04 | 0.71 ± 0.02 | 0.73 ± 0.04 |
| IVSs (mm) | 1.36 ± 0.03 | 1.12 ± 0.04** | 1.04 ± 0.04** | 1.02 ± 0.03** | 0.99 ± 0.04** |
| LVDs (mm) | 2.24 ± 0.07 | 3.20 ± 0.08** | 3.66 ± 0.12** | 3.71 ± 0.14** | 3.83 ± 0.18** |
| LVPWs (mm) | 1.44 ± 0.02 | 1.27 ± 0.05** | 1.23 ± 0.03** | 1.07 ± 0.03** | 1.08 ± 0.02** |
| FS (%) | 44.9 ± 0.7 | 28.2 ± 0.9** | 25.8 ± 1.0** | 27.6 ± 0.7** | 26.7 ± 1.0** |
| FS (% of baseline) | 100 | 63.2 ± 2.1** | 58.8 ± 2.3** | 64.2 ± 1.7** | 61.9 ± 1.9** |
| M-CSF | |||||
| n | 25 | 25 | 23 | 5 | 5 |
| B.W. (g) | 24.8 ± 0.3 | 24.2 ± 0.6 | 25.2 ± 0.4 | 27.8 ± 0.6 | 28.3 ± 0.7* |
| B.W. (%) | 100 | 97.4 ± 1.9 | 101.3 ± 0.9 | 105.2 ± 1.2 | 107.0 ± 1.2 |
| IVSd (mm) | 0.71 ± 0.02 | 0.68 ± 0.02 | 0.67 ± 0.02 | 0.64 ± 0.02 | 0.63 ± 0.04 |
| LVDd (mm) | 4.10 ± 0.06 | 4.52 ± 0.06** | 4.78 ± 0.11** | 4.97 ± 0.26** | 5.14 ± 0.19** |
| LVPWd (mm) | 0.80 ± 0.02 | 0.79 ± 0.03 | 0.80 ± 0.02 | 0.72 ± 0.05 | 0.70 ± 0.04 |
| IVSs (mm) | 1.29 ± 0.02 | 1.18 ± 0.03 | 1.19 ± 0.03†† | 1.12 ± 0.05 | 1.13 ± 0.09 |
| LVDs (mm) | 2.32 ± 0.05 | 3.03 ± 0.06** | 3.18 ± 0.09**†† | 3.22 ± 0.18** | 3.44 ± 0.14** |
| LVPWs (mm) | 1.42 ± 0.02 | 1.28 ± 0.04* | 1.36 ± 0.03†† | 1.24 ± 0.04†† | 1.17 ± 0.05* |
| FS (%) | 43.6 ± 0.6 | 32.9 ± 0.8**††† | 33.5 ± 0.8**††† | 35.2 ± 0.8**††† | 32.9 ± 1.4**†† |
| FS (% of baseline) | 100 | 75.9 ± 2.1**††† | 76.7 ± 2.3**††† | 83.1 ± 1.8**††† | 77.7 ± 3.4**†† |
| G-CSF | |||||
| n | 12 | 10 | 10 | ||
| B.W. (g) | 24.9 ± 0.3 | 24.0 ± 0.3 | 24.8 ± 0.3† | ||
| B.W. (%) | 100 | 96.3 ± 1.4** | 100.3 ± 0.5 | ||
| IVSd (mm) | 0.71 ± 0.04 | 0.77 ± 0.02† | 0.72 ± 0.04 | ||
| LVDd (mm) | 4.06 ± 0.09 | 4.68 ± 0.23* | 5.04 ± 0.15** | ||
| LVPWd (mm) | 0.81 ± 0.06 | 1.08 ± 0.12 | 0.98 ± 0.08 | ||
| IVSs (mm) | 1.27 ± 0.04 | 1.31 ± 0.04†† | 1.37 ± 0.04††† | ||
| LVDs (mm) | 2.32 ± 0.06 | 3.02 ± 0.19** | 3.31 ± 0.10**† | ||
| LVPWs (mm) | 1.40 ± 0.04 | 1.59 ± 0.08†† | 1.57 ± 0.08†† | ||
| FS (%) | 42.9 ± 0.5 | 35.9 ± 1.5**††† | 34.4 ± 0.5**††† | ||
| FS (% of baseline) | 100 | 83.4 ± 3.0**††† | 80.5 ± 1.8**††† |
Data represent the mean S.E.M. n, number: B.W., body weight; IVSd, interventricular septal diastolic thickness; LVDd, left ventricular diastolic dimension; LVPWd, left ventricular posterior wall idastolic thickness; IVSs, interventricular septal systolic thickness; LVDs, left ventricular systolic dimension; LVPWs, left ventricular posterior wall systolic thickness; FS, fractional shortening.
*
P < 0.05 and
**
P < 0.01 versus baseline.
†
P < 0.05,
††
P< 0.01, and
†††
P < 0.001 versus vehicle.