Figure 3.

PH persists in BALB/c mice after Pneumocystis infection is cleared, when CD4 T cells have been temporally depleted. Pneumocystis-infected mice were depleted of CD4 cells for the first 10 days of infection; CD4 cells were then allowed to return. Both mean maximum RVP (A) and RV mass (B) remain elevated at 51 and 63 days after infection, even as the numbers of inflammatory cells decrease during this period (C). CD4⁺ and CD8⁺ are single positive lymphocyte populations, whereas DP lymphocytes are double positive for both CD4 and CD8. Values are means ± SEM, n = 12 (PC-infected 51 days and control) or n = 9 (infected 63 days); P is probability that value is statistically equal to control, noninfected mice.