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. 2007 Sep;171(3):790–799. doi: 10.2353/ajpath.2007.070178

Figure 6.

Figure 6

Persistent PH does not depend on IL-4 signaling. IL-4 KO mice were Pneumocystis-infected and depleted of CD4 cells for 10 days and then sampled at 57 days after inoculation. A: RVP of infected and control IL-4 KO mice. B: Relative right ventricular mass of infected and control IL-4 KO mice. These events occur despite different cellular response to Pneumocystis, as indicated by the profile of BAL cells seen 14 days after infection (C); when compared with immunocompetent mice (see Figure 1G), there is no eosinophil response but a higher recruitment of neutrophils. Values are means ± SEM, n = 5; P is probability that value is statistically equal to control.