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. 2007 Sep;171(3):976–992. doi: 10.2353/ajpath.2007.070345

Figure 1.

Figure 1

A and B: Tail test showing the abnormal limb-clasping reflex in a 12-month-old Tg30tau transgenic mouse (B) by comparison with an age-matched wild-type mouse (A). C: Rotarod testing of wild-type (n = 4 to 8 for each age) and Tg30tau (n = 7 to 13 for each age) transgenic mice at different ages. The time spent on the rotating rod by Tg30tau mice is already significantly shorter at 8 months and dramatically decreases at 10 and 12 months (two-way analysis of variance with Bonferroni post test). D and E: Tissue section showing the cross-sectional aspect of muscle fibers in the quadriceps femoris of 12-month-old wild-type (D) and Tg30tau (E) mice. F: There is a severe atrophy of muscle fibers in Tg30tau mice, as indicated by an important reduction in the mean cross-sectional area of muscle fibers in 11-month-old Tg30tau mice (n = 10) by comparison with wild-type mice (n = 4) (by Student’s t-test). G: Kaplan-Meier survival curves showing the reduced survival of Tg30tau mice (P < 0.0001, by log-rank comparison). *P < 0.05, ***P < 0.001. Scale bar = 60 μm.