TABLE 1.

List of parameters

Parameter	Value	Unit
Channel flux coefficient P	6.32 × 106	nm s−1
Single channel radius Rs	6	nm
Pump flux coefficient Pp	40000	nm μM s−1
Pump dissociation coefficient Kd	0.2	μM
Ca2+ concentration in ER, E	700	μM
Ca2+ concentration in cytosol at rest, c0	0.05	μM
Leak flux coefficient	3.36	nm s−1
Diffusion coefficient D of free cytosolic Ca2+	200	μm2 s−1
Diffusion coefficient Dm of mobile buffer	200	μm2 s−1
Diffusion coefficient Ddye of dye buffer	15.0	μm2 s−1
On-rates of fast buffers:
	50	(μM s)−1
	5	(μM s)−1
	150	(μM s)−1
Dissociation constants of buffers :
	2	μM
	0.15	μM
	2	μM
Total concentrations of buffers:
Bs	80	μM
Bm	300	μM
Bdye	40	μM
Subunit kinetics, note bi = aidi
IP3 binding
a1, a3	80	(μM s)−1
d1	0.008	μM
d3	0.5	μM
Inhibiting, with IP3
a2	0.04	(μM s)−1
d2	12	μM
Inhibiting, without IP3
a4	0.4	(μM s)−1
d4	0.192	μM
Activating
a5	15	(μM s)−1
d5	0.8	μM
Open conformational transition
a0	550	μM
b0	80	μM