Figure 4.

(A). T cell proliferation assessed by %Ki67 expression is shown for CD4⁺ and CD8⁺ T cells. Both CD4⁺ and CD8⁺ T cell proliferation increased following SHIV_sf162p3 infection between 14 to 35 days post inoculation, but returned to baseline levels thereafter. (B). Representative expression of CD95 and Ki67 in CD4⁺ and CD8⁺ T cells in blood from a SHIV_sf162p3 infected macaque (DT54). Percentages of Ki67⁺ CD95⁺ T cells in either CD4⁺ or CD8⁺ T cells are shown in the box of each dot plot. Six-color flow cytometry staining was performed to define proliferating T cells as described in Table 1.