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. 2003 Jan 1;17(1):141–153. doi: 10.1101/gad.250703

Figure 5.

Figure 5

Proximo-distal patterning of the second branchial arch in Fgfr1n7/n7 mutants. Whole-mount in situ hybridization analysis of the expression of Dlx1 (A–D), Dlx2 (E–H), Dlx5 (I–L), and Msx1 (M,N) at E9.5 (A,B,E,F,I,J) and E10.5 (C,D,G,H,K,L,M,N). At E9.5, the patterns of gene-expression in the neural crest of the proximal and distal second branchial arch are similar in wild-type (A,E,I) and Fgfr1n7/n7 (B,F,J) embryos. At E10.5, the distal second branchial arch of both the wild-type (C,G,K,M) and Fgfr1n7/n7 (D,H,L,N) embryos expresses all the genes analyzed. (D,H,L,N) In contrast, no expression of Dlx1 and Dlx2 can be detected in the proximal second branchial arch region in Fgfr1n7/n7 embryos. Arrows mark the distal second arch, arrowhead the proximal region. BA2, second branchial arch.