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. 2003 Jan 1;17(1):88–100. doi: 10.1101/gad.1029903

Figure 1.

Figure 1

Telomerase activity and telomere dynamics in T and V transformed MEF lines. (A) Telomere restriction fragment length analysis of indicated T and V cell lines from passage 6 to 300. Note the gradual decline of telomere length in V cell but not in T cell lines as a function of passage. Human IMR 90 cell line and mTerc+/− MEF cell line were included as telomere length standards. Approximate molecular weight standards are shown. (B) Growth of T and V cell lines after serial passage via the 3T3 protocol. (C) Telomerase reconstitution rescues the growth defects of V cell lines.