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Shh responsiveness is reduced in Gli2−/− skin. Expression of Shh (A,G), Ptc1 (B,H), Ptc2 (C,I), Gli1 (D,J), Gli2 (E,K), and Gli3 (F,L) in E18.5 wild-type (A–F) and Gli2−/− (G–L) skin. The expression of the Shh-responsive genes, Ptc1 and Gli1, is dramatically reduced in Gli2−/− mutants (H,J). (M) Shh induces Gli1 and Ptc1 expression in dermal fibroblasts isolated from wild-type skin, as revealed by RT–PCR analysis. This Shh response is lost in Gli2−/− dermal fibroblasts.
