Table 2.

Necropsy of Brca1 mutant mice at 6.5, 8, and 9.5 mo

Organ tissuesa	Phenotypes	9.5 mo	8 mo	6.5 mo
Mandibular, lymph node	lymphoid hyperplasia, mild	+	+	+
Adrenal	adenoma, cortex, unilateral	+
Thyroid	follicular dilatation, C cell hyperplasia	+
Esophagus	hyperplasia, hyperkeratosis	+
Heart	chronic cardiomyopathy	+		+
Liver	hepatocellular necrosis inflammation		+	+
Colon	goblet cell hyperplasia	+	+	+
Spleen	marginal zone hyperplasia, decreased  extramedullary hematopoiesis	+
Stomach, glandular	eosinophilic cytoplasmic globules	+
Stomach, nonglandular	hyperplasia, hyperkeratosis	+
Ileum	GALT hyperplasia	+		+
Cecum	proliferative typhlitis	+
Kidney	mineralization, minimal, multipfocal		+	+
Mesenteric, lymph node	lymphoid hyperplasia	+	+	+
Testis	tubular degeneration	+
Epididymis	hypospermia	+	+	+
Eye	retina degeneration		+
Bone marrow	granulacytic hyperplasia		+
Inguinal, lymph node	pigment, lymphoid hyperplasia	+
Bulbourethral gland	cystic hyperplasia	+		+
Nasal structures	eosinophilic cytoplasmic globules respiratory  and olfactory epithelium inflammation	+	+

All three mice were alive at time of sacrificing. The 9.5-month-old mouse showed visible signs of aging, as judged by body size, weight, fur appearance, and movement. 

^aOrgan/tissue systems examined include brain, salivary gland, pancreas, trachea, pituitary, thymus, jejunum, liver, gall bladder, lung, duodenum, rectum, skin, seminal vesicles, coagulating gland, urinary bladder, prostate, kidney, eyes, Harderian glands, femur–bone, femur–bone marrow, vertebra, spinal cord, and tongue. Only the ones with abnormalities are listed.