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A proposed model for molecular regulation of Tbx1. Our data support a model in which Tbx1 is directly regulated by Foxc1 and Foxc2 in the head mesenchyme, and Foxa2 in the pharyngeal endoderm, through a common Fox-binding site upstream of Tbx1. Shh signaling functions to maintain the expression of Foxa2 and Foxc2, which subsequently activate Tbx1 expression.
