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. 2003 Feb 15;17(4):488–501. doi: 10.1101/gad.1051603

Figure 2.

Figure 2

Mammary tumorigenesis in chronically induced MTB/TWNT mice. (A) Tumor incidence curves for transgenic mice. A cohort of 52 female bitransgenic MTB/TWNT mice was administered 2 mg/mL doxycycline beginning at 4–6 wk of age and monitored twice weekly for tumor formation. Tumors arose with a median latency of 20 wk of doxycycline induction. No tumors arose in control cohorts that included doxycycline-induced monotransgenic mice (MTB, n = 20; TWNT, n = 15) and uninduced bitransgenic MTB/TWNT mice (n = 9). (B) MTB/TWNT mice develop mammary adenocarcinomas. H&E sections from mammary tumors arising in doxycycline-induced MTB/TWNT mice. The middle panel depicts an area of squamous differentiation seen in a subset of MTB/TWNT tumors.