. 2003 May 1;17(9):1115–1129. doi: 10.1101/gad.1067003

Table 1.

Myc-target genes belong to diverse functional categories

Adhesion/matrix/tissue remodeling
β integrin (ITGB1)^f
Carcinoembryonic antigen (CEACAM5)
Collagen type IV (COL4A1/COL4A2)^c^e
Integrin α 6 (ITGA6)^d^e
Intercellular adhesion molecule 1 (ICAM1)
MUC5B^d
Mucin 1 (MUC1)
Nidogen (NID)^b^c
Plakophilin (PKP1)^c
Plasminogen activator inhibitor-1 (SERPINE1)^f
Tartrate-resistant acid phosphatase type 5 (ACP)^c^f
Ligand/receptor
Bone morphogenetic protein 4 (BMP4)
CD30
CD63/Me491
CD79B/lg β/B29^c
Chemokine HCC-1 (CCL14)^c
Complement receptor 2 (CR2, CD21)^a
EMMPRIN (BSG)
FGFR4
G-protein-coupled receptor (GPR4)
Galanin (GAL)^a
Gastrin receptor (CCKBR)
Hepatocyte growth factor receptor (MET)
Hepatocyte growth factor-like protein homolog (MST1)
IFRD2
Insulin receptor (INSR)
Interleukin-2 (IL2)
Interleukin-11 receptor α chain (IL11RA)
Interleukin-13 (IL13)^c
Lymphotoxin-β (LTB)^c
Melanoma growth stimulatory activity β (CXCL2)^b
MHC class II HLA-SB-β-1^c
Muscle nicotinic acetylcholine receptor (CHRNB1)
Netrin-2 like protein (NTN2L)
NOTCH4
P protein (OCA2)
Prepro-8-arginine-vasopressin-neurophysin II (AVP)
Prostaglandin E2 receptor EP2 subtype (PTGER2)
Transferrin receptor (TFRC)^f
Transforming growth factor β-1(TGFB1)^f
Transforming growth factor β-2 (TGFB2)^b
Transforming growth factor β-3 (TGFB3)^c
Type I σ receptor (σ R1)^f
Structural
β-tropomyosin (TPM2)
Cytoskeletal γ-actin (ACTG1)
Erythrocyte membrane protein 4.2 (EPB42)^c
Lamin A/C (LMNA)
Lamin B2 (LAMB2)
Moesin (MSN)^f
Neurofilament subunit M (NEF3)
Oncoprotein 18, stathmin, Pr22 (STMN1)
Channels/components
AE2 anion exchanger (SLC4A2)
CLCN6
CLNS1A
Na,K-ATPase subunit α 2 (ATP1A2)^c
TIRC7 protein (TCIRG1)
Chaperone/protein folding
Hsc70 (HSPA8)^f
Hsp10 (HSPE1)^f
Hsp60 (HSPD1)^f
Hsp90 α (HSPCAL3)^f
Prohibitin (PHB)^f
Translation/ribosomal protein
Initiation factor 4AI (EIF4A1)
Initiation factor 4E (EIF4E)^f
Initiation factor 5AII (EIF5A2)^f
Poly(A)-binding protein (PABP)
RPL13A
RPL19^f
RPL22^f
RPL27A^f
RPS19^f
RPS6
Translational inhibitor p14.5
Vesicle protein/trafficking
ADP-ribosylation factor 1 (ARF1)
ADP-ribosylation factor 4 (ARF4)
Pex3
Synaptobrevin 2 (VAMP2)
Synaptogyrin 2 (SYNGR2)
Metabolism
Amino acid
AMP deaminase isoform L (AMPD2)
Cystathionine β-synthase (CBS)
Dihydropteridine reductase (QDPR)
FAH
Folylpolyglutamate synthetase (FPGS)
Methylenetetrahydrofolate reductase (MTHFR)
Amine
S-adenosylmethionine decarboxylase (AMD1)
Spermidine synthase (SRM)^f
Carbohydrate
Aldehyde dehydrogenase 2 (ALDH2)
Aldehyde reductase (AKR1A1)
α(1,2)Fucosyltransferase (FUT1)^c
α-Galactosidase A (GLA)
Galactose-1-phosphate uridyl transferase (GALT)
Glucose transporter (SLC2A4)
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
Energy metabolism
Uncoupling protein 1 (UCP1)^c
Uncoupling protein 3 (UCP3)
Heme
α-Globin (HBA1)
α-Globin (HBA2)
β-Globin (HBB)
Ferrochelatase (FECH)^c
Heme oxygenase-1 (HMOX1)^c^d
Hydroxymethylbilane synthase (HMBS)
Uroporphyrinogen decarboxylase (UROD)
Iron
Frataxin (FRDA)^f
Melanotransferrin (MF12)

Lipid
Acyl-CoA oxidase (ACOX1)
Fatty acid synthase (FASN)^f
Medium chain acyl CoA dehydrogenase (ACADM)
Prosaposin (PSAP)^c
Nucleotide
AIRC (PAICS)^f
AMP deaminase (AMPD3)
Cad^f
Deoxycytidine kinase (DCK)
GPAT (PPAT)^f
Platelet-derived endothelial cell growth factor (ECGF1)^b^c
Steroid
11 β-hydroxysteroid dehydrogenase 2 (HSD11B2)
Steroid 5-α-reductase (SRD5A1)
Other
Aconitase (ACO2)
α-Mannosidase IIX, MIIX (MAN2A2)
Epoxide hydrolase (EPHX1)^e
Glutathione S-transferase (GSTP1)^f
Inosine monophosphatase 2 (IMPA2)
Microsomal glutathione transferase (MGST1)^f
Nitrilase homolog 1 (NIT1)
Pyruvate dehydrogenase α (PDHA1)
Reduced folate carrier (SLC19A1)
Miscellaneous
Angiotensin-I converting enzyme (ACE)^c
bA18I14.4^a
CFDP1/BCNT
dbi/acbp (diazepam-binding inhibitor/acyl-CoA binding protein)^f
FCI-12
Growth arrest specific 11 (GAS11)
Human homolog of rat insulinoma gene (rig)
ISG20
JM26 protein
MAGE-3 antigen (MAGEA3)
Myeloperoxidase (MPO)
Outer membrane receptor Tom20 (TOM20)
Prostatic acid phosphatase (ACPP)^c
QM
Ring zinc-finger protein ZNF127-Xp (MKRN4)^c
SLC9A3R2
Proteolysis
Amyloid precursor protein (APP)^f
Arylsulfatase B (ARSB)
Cathepsin F (CTSF)
Cystatin B (CSTB)^f
Cystatin D (CST5)^d
Elafin (PI3)^e
Mif1/KIAA0025 (HERPUD1)^f
Nexin-1 (PN1)^d
Proteasome subunit HC5 (PSMB1)
Ubiquitin-binding protein p62
Ubiquitin–52-amino-acid fusion protein (UbA52)
Von Hippel-Lindau tumor suppressor (VHL)^a
Wegener's granulomatosis autoanitgen proteinase 3 (PRTN3)
Signal transduction
Acetylcholinesterase (ACHE)^a
Adenomatous polyposis coli (APC)

AHSG^c
AKAP1
blk^c
Cyclophilin 40 (PPID)^f
Cytosolic phospholipase A2 (PLA2G4A)
Glycogen synthase kinase 3 β (GSK3B)
Helix–loop–helix basic phosphoprotein (G0S8)
hper 1 (PER1)
mdm2
NRAS^f
Protein phosphatase-1 regulatory subunit 7 (PPP1R7)
PTEN
RCC1
RhoG (ARHG)
src-Like adaptor protein (SLAP)^c
Thioredoxin (TXN)^f
TSC2
Anti/proapoptosis
bax^f
BBC3/PUMA/JFY1
BCL2
BCL2L12
Caspase 8 (CASP8)
Caspase 9 (CASP9)^c
Familial Alzheimer's disease (STM2)
MCL1 and MCL1 delta S/TM
NOD1
Nuclear regulatory factors
BN51^f
Histone deacetylase 3 (HDAC3)
Lamin B receptor (LBR)
Menin (MEN1)^a^b
Nonhistone chromosomal protein HMG-17 (HMGN2)^f
OZF (ZNF146)
Poly(ADP-ribose) polymerase (PPOL)
SIRT1 (Sir2-like protein)
Nucleolus/RNA-binding protein
DKC1
Histone stem–loop-binding protein (SLBP)
hnRNPA1 (HNRPA1)^f
hnRNPA2/B1 (HNRPA2B1)
hPOP1
JKTBP2, JKTBP1 (HNRPDL)
Nucleolin (NCL)^f
Proliferating cell nucleolar protein P120 (NOL1)
Putative RNA-binding protein 3 (RBM 3)
Surf-6 (SURF6)
Tis11d
U50′ snoRNA, U50 snoRNA: nonprotein coding (U50HG)
Transcription factors
Achaete-scute homolog 2 (ASCL2)
Activator of transcription 6 (STAT6)
ATF4
ATFa
B-myb (MYBL2)^b
c-jun proto oncogene (JUN)
CCAAT/enhancer binding protein α (CEBPA)^f
Chronic lymphatic leukemia protein (BCL3)
E2F1^f
ear1 (NR1D1)
EGR3

elk1 (ELK1)
Erythroid Kruppel-like factor (ELKF)
ets2 (ETS2)^f
fra-1 (FOSL1)^f
HB9 homeobox (HLXB9)
Helix–loop–helix protein (TCF12)
HOXD13^d
HRY (Hairy, HHL, HES-1)
Hypoxia-inducible factor 1 α (HIF1A)
Id2^d^f
Id3
Insulinoma-associated (INSM1)^b
Interferon regulatory factor 2 (IRF2)
Interferon regulatory factor 3 (IRF3)
junB (JUNB)
L-myc (MYCL1)
MBP 1 (ENO1)^f
nm23-H1 (NME1)^f
Retinoic acid receptor α (RARA)^f
Retinoic X receptor B (RARB)

Single-minded 2 (SIM2)^d
Smad7 (MADH7)
TRIDENT/HFM11 (FOXM1)
Wilms tumor (WT1)
DNA maintenance/repair
Apurinic/apyrimidinic endonuclease (APEX)^f
β-Polymerase (POLB)
brca2
DNA polymerase δ small subunit (POLD2)^f
DNA-PKcs (PRKDC)
H4 histone (H4/b)
H4 histone (H4/e)
Histone (H2AZ)^f
MCM7
NBS1
NTHL1
Prothymosin α (PTMA)^f
Telomerase reverse transcriptase (TERT)^f
Topoisomerase (TOP1)^f

The 257 genes identified within the high-affinity group of Myc-targets (see Results) are listed and assigned to a functional category. The genes qualify as high-affinity targets in all cell lines tested, unless selectively indicated: ^aU-937, ^bHL60, ^cP493, ^dT98G, ^eWS1. Where applicable, the HUGO nomenclature is used (http://www.gene.ucl.ac.uk/nomenclature). ^fPreviously identified Myc-regulated genes (http://www.myc-cancer-gene.org/index.asp).