Table 2.
Partial list of the dMax network target loci
| Biological pathway/molecular function
|
dMnt targets
|
dMax targets
|
dMyc targets
|
|---|---|---|---|
| Actin/cytoskeleton/cell migration | Dmn, nup44A, Tm1, Sop2, CG6546, CG25C, Dlc90F, nop5, bif | nup44A, Tm1, Arp11, bif, CG15669, puc, Klp3A | Tm1 |
| Cell cycle regulators | Myt1, ial, slbp | ial, cdk4, cdc2, cdc2c, Rbf, CycJ, CycC, CycD, stg | cdk4, CycA, CycB, CycB3, Rbf |
| Cell death | Dredd | Dredd, Dcp-1, Ice, debcl | Reaper L |
| Channels/transports | CG10444, icln | CG10444, Nrv1, Nhe1, icln | rpk, icln |
| Chromatin | HP1b, HmgD, Df31, Nap1, Caf1 | HP1b, HmgD, Caf1 | HP1b, fs (1) Ya |
| Immunity Mitochondria biogenesis, structure, function | FK506bp1, Dredd, Rel, PGRP-LE Tim10, Tim9, mRSp30, mRp19, mRpS7, TFAM, Ferrochelatase | FK506 bp1, Myd88, Rel, PGRP-LE, CG10535, CG3829 Tim10, mRpS30, mRp19, mRpS7, TFAM, colt | Rel Tim10, mRpL10, mRpS7, TFAM, CG3476, mge |
| Nucleolus | CG12909, CG8939, Surf6 | CG1135 | CG1135, CG12909, Rpp30, Surf6 |
| Peptidyl prolyl cis-transisomerase | Fk560bp1 | CG3511, FK506bp1, FKBP59 | CG5482, cyp33 |
| Protein synthesis/Ribosome | Aast-g1n, eIF6, mRpL19, mRpS30, mRpS7, RpL1, RpS5, RpS9, Nmd3, Surf6, CG1475 | bonsai, cg1475, mRpL19, mRpS7, RpL1, eIF6, pelo | RpL1, RpL19, pelo, mRpS7, mRpL1, RpS12, RpS13, RpS9, Surf6 |
| Replication/DNA repair | RnrS, CG8142, pms2 | RnrS, Rfc40, Mcm2, Mcm6, SPT4, Orc1, mus209, CG8142 | RnrS, UbcD6 |
| RNA binding | CG11738, CG12909, CG14230, CG5589, CG8636, CG8862, mod, Nmd3, Rbp1, SC35, SF2, Slbp, tra2, U2af38 | BcDNA: GH01073, CG11738, CG14230, CG1704, CG5589, CG8862, Hrb98DE, mxc, Nmd3, qkr58E-1, Rbp1, SC35, snf, Srp54 | CG10214, CG11738, CG12909, CG8862, cyp33, mod |
| RNA methyltransferase | CG11837, CG5220, CG7319, CG7818 | CG5220, CG7319 | CG1837, CG5220 |
| Signaling | aay, CG1815, CG4527, CG6805, LD08534 | loco, pak3, spz, grk, PP2-AB, puc, stg, cg66805, LD08534, aay | aay, LD08534 |
| Small GTPases GTP binding proteins | Rab14, RhoL | Rab17, Ran, Rap21, Ras85D, RhoL, Arf84F | Rab11 |
| Splicosome | CG10754, CG4980, CG6876, SC35, SF1, SF2, SmB, U2af38 | SC35, Snf, Srp54 | |
| Synaptic vesicles traffic | Syx13, Syx16, Syx17, Syx18, Syndapin, usnp, Rop, KdelR | Syx17, Syx18, Arf84D, Syndapin, Rop, KdelR | Syx13, CG8862 |
| Transcription factors | bic, Max, DREF, Pan, Ell, TFAM, Rel, Jra, Med6 | bic, DREF, bigmax, myb, Xbp1, Rpll33, Rbf, TFAM | bic, bigmax, E2F2, Rel, Rbf, TFAM |
| Transcription initiation and elongation | Taf55, Tfb2, Cyp1 | Taf60-2, Cyp1 | Taf60-2, Cyp1 |
| Transferase transferring glycosyl groups | CG18012, CG4802, CG5537, CG6437, CG9249 | CG5220, CG7319, CG9249 | CG3434, CG4802, CG5537, CG9249 |
| Translation factors | EfTuM, Adam, CG5705 | EfTuM, Adam, eif6, eif4A | Adam |
| Ub-proteasome | CG5384, CG5505, smt3, UfD1-like, Rpn5, Rpn7, Pros25, Pros26 | CG5384, smt3, Ufd1-like, Rpn5, Rpn7, Pros45, Tbp1, Uba1 | UbcD6, smt3 |
Standardized gene annotation was applied from the Drosophila Genome Ontology database (release February 2002). Only annotations in the biological process and molecular function categories with three or more targets are listed. A list of the network target genes can be found in Supplemental Material S2. Shared targets between all three proteins are in italic.