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. 2003 Jun 1;17(11):1366–1379. doi: 10.1101/gad.256103

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Figure 5. — Histology and light responsiveness in the retina of wild-type, young, and old mPer1^-/- mCry2^-/- mice. Gomori trichrome (A) and lipofuscin (B) staining of retinal sections of wild-type (first row), young mPer1^-/- mCry2^-/- (second row), old mPer1^-/- mCry2^-/- (third row), mPer1^-/- (fourth row), and mCry2^-/- mice (fifth row). Retinal layers are indicated on the left. PRL, potoreceptor layer; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. (C) Immunohistochemistry analysis of light-induced CREB Ser 133 phosphorylation in the retina. (Left panels) Immunostained retinal sections of control animals without light exposure. (Right panels) Animals 1 h after light exposure (400 lx, 15 min) at ZT14. (D) Immunohistochemistry analysis for (unphosphorylated) CREB in the retina at ZT14. Bar, 10 μm.