Table 1.
Correlation of p27 levels with Src activation and other clinical/pathologic variables in 482 primary human breast cancers
| Variables | Low p27 n=177 | High p27 n= 305 | p valuea |
|---|---|---|---|
| n (%) | n (%) | ||
| Tumor Grade
1 2 3 Missing |
9(6.8) 56(42.1) 68(51.1) 44 |
25(10.3) 126(52.1) 91(37.6) 63 |
0.04 |
| Nodal status
negative positive not tested |
55(35.5) 100 (64.5) 22 |
119(48.0) 129(52.0) 57 |
0.01 |
| ERb
negative positive missing |
78(44.3) 98(55.7) 1 |
60(19.9) 241(80.1) 4 |
<10−4 |
| PRc
negative positive missing |
84(53.9) 72(46.2) 21 |
77(29.0) 189(71.1) 39 |
<10−4 |
| LVId
not present present unknown/missing |
83(55.7) 66(44.3) 28 |
178(65.0) 96(35.0) 31 |
0.06 |
| Menopausal Status
post pre missing |
95(54.0) 81(46.0) 1 |
187(61.5) 117(38.5) 1 |
0.11 |
| Src
0 1 2 3 |
40(22.6) 55(31.1) 51(28.8) 31(17.5) |
73(23.9) 126(41.3) 72(23.6) 34(11.2) |
0.05 |
| Src
0 or 1 2 or 3 |
95(53.7) 82(46.3) |
199(65.3) 106(34.7) |
0.01 |
a
chi-square test to compare the frequency and t-test to compare the mean.
b
ER = estrogen receptor
c
PR = progesterone receptor
d
LVI= lymphovascular invasion